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VOL. 11, ISSUE 2 (2026)
Drug-induced kidney injury from Acid-Suppressive Therapy: Mechanisms, clinical outcomes, and role of therapeutic nutrition
Authors
Purva Gopal Sharma, Payel Roy, Souvik Tewari, Poulami Biswas, Vijayalakshmi P
Abstract
Acid-suppressive
therapies, particularly proton pump inhibitors (PPIs) and histamine-2 receptor
antagonists (H2RAs), are widely prescribed for the management of acid-related
gastrointestinal disorders. Despite their clinical efficacy and perceived
safety, emerging evidence links long-term and inappropriate use of these agents
to drug-induced kidney injury (DIKI). This review explores the mechanisms
underlying renal injury associated with acid-suppressive therapy, including
acute interstitial nephritis (AIN), acute kidney injury (AKI), and progression
to chronic kidney disease (CKD). The immunological, inflammatory, and oxidative
pathways implicated in renal damage are discussed. Clinical outcomes, risk
factors, and diagnostic challenges are highlighted. Additionally, the role of
therapeutic nutrition in preventing and managing renal complications is
emphasized, focusing on electrolyte balance, antioxidant intake, and dietary
strategies for renal protection. This review underscores the importance of
rational drug use, early detection of nephrotoxicity, and integration of
nutritional interventions to improve patient outcomes.
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Pages:1-6
How to cite this article:
Purva Gopal Sharma, Payel Roy, Souvik Tewari, Poulami Biswas, Vijayalakshmi P "Drug-induced kidney injury from Acid-Suppressive Therapy: Mechanisms, clinical outcomes, and role of therapeutic nutrition". International Journal of Medicine Research, Vol 11, Issue 2, 2026, Pages 1-6
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