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VOL. 11, ISSUE 2 (2026)
Role of Mannich base derivatives in the development of novel anticonvulsant drugs: A comprehensive review
Authors
Raju Kumar, Aryadeep Tyagi
Abstract
Mannich base derivatives represent a
fascinating class of organic compounds that have garnered significant attention
in medicinal chemistry due to their diverse biological activities. The Mannich
reaction, a three-component condensation involving a primary or secondary
amine, a carbonyl compound, and a nucleophile, has been extensively explored
for the synthesis of novel anticonvulsant agents. This review comprehensively
examines the role of Mannich base derivatives in anticonvulsant drug
development, focusing on their structural features, mechanisms of action,
synthetic methodologies, and structure-activity relationships (SAR). The
significance of these compounds lies in their ability to modulate neuronal
excitability through multiple pharmacological targets, including voltage-gated
ion channels, GABA receptors, and enzyme inhibition pathways. Recent
developments in this field have yielded promising candidates with improved
efficacy, reduced toxicity, and enhanced bioavailability compared to
conventional anticonvulsants. This review synthesizes current knowledge on
Mannich base-derived anticonvulsants, highlighting key examples from
literature, discussing their physicochemical properties, and exploring future
perspectives for drug discovery and development.
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Pages:7-11
How to cite this article:
Raju Kumar, Aryadeep Tyagi "Role of Mannich base derivatives in the development of novel anticonvulsant drugs: A comprehensive review". International Journal of Medicine Research, Vol 11, Issue 2, 2026, Pages 7-11
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