Background: Photoaging results from cumulative ultraviolet
exposure and oxidative stress, leading to pigmentary changes, uneven texture,
and fine wrinkles, [1, 2] Ferulic acid is a plant-derived phenolic
compound with antioxidant, anti-inflammatory, depigmenting, and photoprotective
properties and has emerged as a promising agent for facial rejuvenation, [3,
4] However, clinical evidence supporting its efficacy as a monotherapy
remains limited, [5]
Methods: This prospective interventional study included 25
patients aged 25–50 years with clinical features of photoaging. Patients
underwent 6–8 sessions of ferulic acid peel at three-week intervals. Clinical
improvement was assessed using the Physician’s Global Aesthetic Improvement
Scale (GAIS) and patient satisfaction scores. Statistical analysis was
performed using paired t-test.
Results: An overall clinical improvement of 60–70% was
observed. Mean GAIS scores showed a statistically significant reduction
post-treatment (p < 0.001). More than 80% of patients reported good to very
good satisfaction. Adverse effects were mild and transient.
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