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International Journal of
Medicine Research
ARCHIVES
VOL. 11, ISSUE 1 (2026)
Therapeutic efficacy and aesthetic outcomes of ferulic acid peel for facial rejuvenation
Authors
Dr. Shruthi S B, Dr. Manjunatha P, Dr. Sunil S G
Abstract

Background: Photoaging results from cumulative ultraviolet exposure and oxidative stress, leading to pigmentary changes, uneven texture, and fine wrinkles, [1, 2] Ferulic acid is a plant-derived phenolic compound with antioxidant, anti-inflammatory, depigmenting, and photoprotective properties and has emerged as a promising agent for facial rejuvenation, [3, 4] However, clinical evidence supporting its efficacy as a monotherapy remains limited, [5]

Methods: This prospective interventional study included 25 patients aged 25–50 years with clinical features of photoaging. Patients underwent 6–8 sessions of ferulic acid peel at three-week intervals. Clinical improvement was assessed using the Physician’s Global Aesthetic Improvement Scale (GAIS) and patient satisfaction scores. Statistical analysis was performed using paired t-test.

Results: An overall clinical improvement of 60–70% was observed. Mean GAIS scores showed a statistically significant reduction post-treatment (p < 0.001). More than 80% of patients reported good to very good satisfaction. Adverse effects were mild and transient.

Conclusion: Ferulic acid peel is an effective and well-tolerated modality for facial rejuvenation with minimal downtime.
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Pages:51-53
How to cite this article:
Dr. Shruthi S B, Dr. Manjunatha P, Dr. Sunil S G "Therapeutic efficacy and aesthetic outcomes of ferulic acid peel for facial rejuvenation". International Journal of Medicine Research, Vol 11, Issue 1, 2026, Pages 51-53
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