Background: Acute febrile illnesses with seizures in infancy are neurological emergencies associated with high morbidity and risk of long-term developmental impairment. Early recognition and structured neurological assessment are essential for prognosis and rehabilitation planning.

Case Description: We report the case of a 6-month-old male infant presenting with high-grade fever, recurrent generalized seizures, altered sensorium, and regression of motor activity. The illness was preceded by persistent fever and excessive high-pitched crying. Clinical examination revealed hypertonia, extensor posturing, exaggerated deep tendon reflexes, and bilateral positive Babinski sign, indicating central nervous system involvement. The child required Pediatric Intensive Care Unit (PICU) admission and anticonvulsant therapy.