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VOL. 10, ISSUE 2 (2025)
Evaluation of cytotoxic activity of Ficus carica latex extract on cancer cell line (Caco-2) and HDFn cells: MTT-based cytotoxicity and GC-MS characterization
Authors
Hanan KA Al Hamdany, Farooq IM Aljubouri
Abstract
The present study aimed to investigate the
therapeutic effects of fig latex extract on Caco-2 and HdFn cancer cell lines.
The toxicity of fig latex was determined using the MTT assay against Caco-2.
The active chemical compounds in the latex were also identified using gas chromatography-mass
spectrometry. According to the data, fig latex showed selective activity in
inhibiting the growth of Caco-2 cells compared to HdFn cells, with an IC50
value of 92.03 µg/mL for Caco-2 cells and 122.5 µg/mL for HdFn cells. Fig
latex-treated Caco-2 cells also showed a significantly higher inhibitory effect
compared to HdFn cells. Thus, our results suggest that fig latex may be a
promising treatment for colon cancer in humans.
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Pages:1-4
How to cite this article:
Hanan KA Al Hamdany, Farooq IM Aljubouri "Evaluation of cytotoxic activity of Ficus carica latex extract on cancer cell line (Caco-2) and HDFn cells: MTT-based cytotoxicity and GC-MS characterization". International Journal of Medicine Research, Vol 10, Issue 2, 2025, Pages 1-4
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