Background: The fastest-spreading mosquito-borne disease, dengue fever, has become a serious public health issue in tropical and subtropical countries like Bangladesh. It has been discovered that the dengue load is highest in children, adolescents, and young adults globally; babies are especially vulnerable to infection. Objective: To observe the role of antibiotics in pediatric dengue virus infection.

Methods: From July to October 2023, this cross-sectional study was conducted in the inpatient department of Bangladesh Shishu Hospital & Institute.

Results: This study included 722 hospitalized patients who tested positive for dengue in a rapid test. The largest percentage of positive patients were between the ages of 1 and 5 (38%), followed by those between the ages of 5 and 10 (32%). The most frequent symptom was vomiting (49%), followed by fever (100%). Every patient had received antibiotics, and as their hospital stay lengthened, so did the variety of medications they took. Among the administrated antibiotics, the highest percentage was levofloxacin (63), followed by meropenem (26), ceftriaxone (9), and ciprofloxacin (7) respectively. The length of the hospital stay was positively correlated with the use of multiple antibiotics. Patients with an average stay of 5 days took only one antibiotic, whereas those with an average stay of 6, 7, and 8 days used 2-4 different types of antibiotics. Among 722 patients 87 patients got Levofloxacin with Ceftriaxone and Meropenem, Ciprofloxacin with Levofloxacin and Meropenem (18), and Meropenem with Ceftriaxone and others (91) respectively.