Objectives: 1. To study the clinical profile, EEG and CT scan abnormalities in partial seizures. 2. To establish, if possible, any correlation between clinical profile, EEG and CT scan findings.

Design: Prospective study of fifty (50) patients with partial seizures.

Setting: The Study was done at Janaki Medical College Teaching Hospital in the department of Internal Medicine.

Subjects: Patients (more than 10 years) with clinical evidence of partial seizure onset with or without secondary generalization and patients with generalized seizures from the onset who have an abnormal focus on EEG/CT scan were included. Patients with generalized seizures from the onset who have normal EEG/Ct scan were excluded.

Results: Male to female ratio was 3.5:1. Maximum incidence of onset of seizure (36%) was seen in second decade of life. In most of the patients, duration of illness was less than 6 months (82%) at the time of presentation and majority of patients came after 2-10 episodes of seizures. Family history of seizure was found in 12% of patients. Precipitation factors were noted in 20% of patients and mental upset being the most common precipitating factor accounting for 6% of patients. One female patient had firs episode of seizure during pregnancy and for 2 others seizure got aggravated during menstruation. Simple partial seizure with secondary generalization was the commonest type (36%) of seizure. Post-ictal headache and confusion (52%) were the most common post-ictal symptoms.

EEG was abnormal in 46% of patients. Lateralized spikes/sharp and slow wave complexes was the most common (52%) form of epileptiform abnormalities.

CT scan abnormalities were detected in 74% of patients, which included ring or disc- enhancing lesion (60%), vascular (6%) and calcification (8%). CT scan abnormalities were common in elderly age group as compared to young (p value 0.1989) and seizure duration of less than 6 months as compare to longer seizure duration (p value 0.37121). CT scan abnormalities were detected in 42% of patients with normal EEG records and 32% of patients with abnormal EEG records. 14% of patients had abnormal EEG records but had normal CT scans. 16 out of 23 patients with EEG abnormalities had abnormal CT scan; while 21 CT scan abnormalities were detected out of 27 patients with normal EEG (p value 0.50935).

ELISA for cysticercosis was positive in 33.3% of patients with ring or disc-enhancing lesions in the CT scan. It was positive in 30.8% of patients with single lesion and 50% in multiple lesions.

Conclusion: CT scan is potentially convenient and safe technique that is valuable in the clinical investigation of patients with partial seizures, especially in patients with late - onset partial seizures and seizure duration of less than 6 months.