Introduction: Steatorrhea occurs when the pancreatic exocrine function is less than 10%. In CP, steatorrhea is reported in 22.9%¹. In a survival analysis comparing carcinoma in chronic pancreatitis (CCP-Ca) and de-novo adenocarcinoma pancreas (denovo-Ca), steatorrhoea was incidentally detected as one of the poor prognostic factors impairing the survival.

Aim: To correlate steatorrhoea with overall survival and other clinical parameters in CCP-Ca and De-novo carcinoma pancreas.

Methodology: Retrospective study conducted on CCP-Ca and denovo-Ca resected between 01/01/2004 and 31/12/2013; followed-up for overall survival. The relevant statistical test including Kaplan-Meir and Cox-regression were done using SPSS-22.

Results: Among 137 patients studied, 59 (43.1%) were CCP-Ca and 78 (56.9%) were denovo-Ca. Steatorrhoea was there in 29.1% of CCP-ca and 28.2% of denovo-Ca; which was not statistically significant (p=0.901). Chi-square showed significant differences comparing diabetic status (28.8% vs 69.5%, p=0.133); serum bilirubin (p=0.009; 0.183) and serum albumin (0.45; 0.505 and hypoalbuminaemia (71.2% va 28.8%; p=0.088. 0.255; 0.026) which was more significant in CCP-Ca. On Kaplan-Meier curve it had association with survival (Log Rank test p=0.003 in CCP-Ca, p=0.084 in denovo-Ca). On Cox regression analysis steatorrhoea was poor prognostic factor impairing the survival in CCP-Ca (p=0.005; HR=2.985; 95%CI=1.392-6.404), but not in denovo-Ca.