Prostate Cancer are the leading cause of death, disability and suffering to increasingly large number of men and therefore calls for concerted efforts from all and sundry. Based on this study was designed to determine the prevalence and risk factors associated with prostate cancer among patients in Enugu State Nigeria from 2014 to 2018. Four research questions and four null hypotheses guided the study. Descriptive, retrospective epidemiological survey design was used for the study. The uniform data format was designed based on information contained in the medical folders of prostate patients of the study. Data collected were analyzed using descriptive statistics of frequency counts and percentages to answer the research question while Chi-square statistic was used to test the null hypotheses at 0.05 level of significance. The result of study among others showed that the prevalence of Prostate Cancer among patients in Enugu State as found in this study was high in the year 2018 and 2014 for Prostate Cancer patients respectively. The prevalence of prostate cancer differed significantly from 2014 to 2018 (p > 0.05). based on the findings and conclusions, it was recommended among others that both federal and state governments should build additional hospitals and health centers that offer specialized services for prostate cancer to males from the age of 35 partner with their respective communities.