Backgroundand Aims: There is report of increasing association of thyroid disorders in HIV positive patients. Currently there are insufficient data to recommend routine screening for thyroid disorders in asymptomatic HIV patients, hence this study was undertaken to resolve these issues. Methods: This is a comparative descriptive study of 90 seropositive HIV patients which was taken for convenience conducted at MGM Medical college Kishanganj Bihar. Results: Overt hypothyroidism was found in 3.33% patients, subclinical hypothyroidism was found in 8.89% patients, isolated low FT4 was found in 3.33% patients while sick euthyroid syndrome was found in 26.67% patients, none of the patient was found to be had hyperthyroidism. As the disease progresses FT4 and FT3 level were decreased while TSH level was increased. A direct positive correlation between FT4, FT3 and CD4 count was established while a negative correlation between S.TSH and CD4 count was found. Mean FT3 and FT4 levels were lower in patients on HAART while mean TSH level was higher in patients on HAART. Conclusion: Thyroid dysfunction in HIV patients were largely asymptomatic.There was a direct correlation between WHO clinical stage and FT3 and FT4 levels. Thyroid Stimulating Hormone level increased as CD4 count decreased. Patients on HAART had a higher prevalence of subclinical hypothyroidism.