Our current research includes shedding light on Ibn Sina’s Canon of Medicine book, which is the comprehensive encyclopedia of medicine and the source that researchers refer to until the present time. The Canon of Medicine is divided into five medical volumes that are taught in many universities in the world. It includes many explanations, including an explanation of the sciences of anatomy, an explanation of drugs, compounds, diseases and their most important causes, inferences and partial treatments with a simple medicine, and other explanations, as Ibn Sina revealed many scientific, experimental and laboratory theories. Some pathological conditions that are related to the brain have been referred to. These cases are related to Ibn Sina's Book of Canon of Medicine. The research also included a set of statistics that we documented of the 250 primary headache cases; (tension headache 130, migraine headache 100, and cluster headache 20), and the 250 secondary headache cases; (cervicogenic headache 120, fever associated headache (flu, covid, and meningitis) 35, and brain tumor, and others 15). The total number of headache cases that we have documented is 420 cases in various cases, with a variety of treatment methods and the selection of the appropriate medication to treat each case alike.