Catharanthus roseus has antioxidant effects, one of which plays a role in inhibiting the aging process. The purpose of this study was to determine the antioxidant content of the Catharanthus roseus. The literature study used in vivo, in vitro, in silico research articles, and literature review articles from national and international journals accessed from Google Scholar, Elsevier, Science Direct, and PubMed using the keywords Catharanthus roseus, antioxidant. We used 13 relevant articles in this literature review. Catharanthus roseus is an evergreen subwerb or herbaceous plant that grows to a height of 1 m. Antioxidants in a chemical sense are electron donors and biologically antioxidants are compounds that are able to overcome the negative effects of oxidants in the body such as damage to vital elements of body cells. Catharanthus roseus has antioxidant effects that are beneficial for the anti-aging process. In addition, Catharanthus roseus also has good antioxidant potentials throughout its parts under drought stress.