Background: Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Investigating the prevalence of internal diseases and causes of hospitalization of patients in the west of Iraq can be helpful for healthcare programmers in scheduling a healthy and joyful and reducing their mortality and morbidity. Objectives: To determine the etiological factors, outcomes among hospitalized patients with internal medicine disease. Methods: A cross sectional study was carried out on patients with internal medicine disease admitted to al_amiriyah General Hospital, during the period between 1^st January to 1^st September 2019. A total of 307 patients 189 male and 118 female who was admitted to the medical floor constituted the study group. Results: There were (61.56%) male’s patients and (38.44%) female’s patients. The prevalence of various causes of in this study was: Obstructive pulmonary diseas (19.21%), Pneumonia (11.41%), Gastroenteritis (11.08%), Peptic ulcer disease (9.45%), cerebrovascular accidents (7.49%), Heart failure (6.84%), Chronic Bronchitis (6.19%), Diabetes mellitus (6.19%), Urinary tract infection (4.89%), Migraine (4.56%), Liver failure (3.92%), Chronic renal failure (3.58%), Hepatitis (3.27%) and Deep Venus thrombosis (1.96%) of the patients. Conclusions: The incidence of internal medicine disease is high in our hospital. Occurrence of the internal disease in rural population more than in urban one. Case _fatality rate was low in our study. The Obstructive pulmonary disease was the leading causes of admission fallowed by pneumonia.