Objective: To study the reasons behind hysterectomy and most common approach. Method: Retrospective study done in department of Obstetrics and Gynecology at Al-Salam Teaching Hospital, Mosul, from 1^st Jan 2012 to 1^st Jan 2013 for women who undergone hysterectomy for different reasons. Results: 105 patients did hysterectomy, their age range from 15 to 75 years old, more than half 56.2% from 40-49 years. Most common indication is DUB 34.3%, fibroid 27.6%, uterine carcinoma 13.3%, emergency peripartum hysterectomy 9.5% weather PPH or morbid adherent placenta, ovarian tumor and uterine prolapse 4.8% for each one, non-specific cause 3.8% and mental retardation 1.9%. 95.2% did abdominal approach and 4.8% vaginal approach. Conclusion: Bleeding is the most important cause weather gynecological or obstetric cause and try to find a ways to reduce this.