Background: Normal saline can be used to cleanse, irrigate, or moisturize wounds. It is also used in IV fluids for dehydration and in other uses. Objective: is to evaluate the effectiveness of normal saline wash in treatment of infected wound by decreasing the time needed for complete healing and duration of antibiotic use Patients & Methods: Randomized prospective studies of two hundreds twenty patients done by 5th unite of surgical department in AL-Yarmouk teaching hospital from January 2010 to February 2012. Patients with infected surgical wounds who underwent emergency operations to identify the effect of cleansing by normal saline on time required for healing and duration of antibiotic use. Hundred cases were washed with normal saline (group A); 120cases were not washed with normal saline (group B). Wound swab was taken from all patients for culture and sensitivity and made a comparison between the two groups. Results: Regarding (A) group N/S wash had accelerated healing rate in 28 patients (28%) those include 8 cases of perforated viscous (perforated duodenal ulcer) (8%), and 20 patients were soft tissue infection (20%), while N/S was moderately accelerating the wound healing process in 63 patients (63%) in whom 2 patients (2%) were perforated viscous(perforated duodenal ulcer) and 40 patients (40%) were perforated appendicitis and 21 patients (21%) were penetrating injuries (small and large bowel injuries).N/S was less effective in 9 patients (9%) in whom 5 patients (5%)were penetrating injuries (multiple large bowel injuries),3 patients (3%) were perforated appendicitis and 1 patient (1%) was abdominal wall TB of soft tissue(chronic sinuses). In group B 9 patients (7.5%) had a good response five of them were soft tissue infection (4%) and four were perforated duodenal ulcer (3.3%), 100 patients (83.33%) were moderately respond in whom 6 patients (5%) were perforated duodenal ulcer,20 patients (16.6%) were soft tissue infection, 52 patients (43.3%) were perforated appendicitis and 22 patients (18.3%) were penetrating injuries (small and large bowel injuries) and 11 patients of group B (9.16%) were poor response in whom 8 patients (6.6%) were perforated appendicitis and 3 patients (2.5%) were penetrating injuries (small and large bowel injuries). Conclusions: Normal saline wash affect wound healing by acceleration of granulation tissue appearance, decrease antibiotic duration and cost effect.