Background: Thalassemia is defined as a complete absence of one or more of the four globins in the red blood cells due to the deletion of or nonfunctioning of one or more genes. Osteoporosis is a universal medical problem, affecting both genders. Objective: To find out any relationship between osteoporosis and thalassemia in our community Materials and Methods: In the current study, 74 thalassemic major patients (36 male and 38 female) between 1 to 30 years (mean 12y) were included at AL Salaam General Teaching Hospital and in Ibn AL Atheer Pediatric Teaching Hospital, (Thalassemia center) in Iraq/ Mosul city from 1st June 2010 to 1 July 2011. Assessment was done by one rheumatology research physician and one radiologist for the bone densitometry examination. Results: The frequency of osteoporosis in thalassemic Iraqi patients Daul X- Ray absorptiometry scans (DEXA) has been found to be 67.5%, while osteopenia has been found in 9.4% and normal Bon Mass Density (BMD) in 22.9%. Conclusions: Osteoporosis in thalassemic Iraqi patients was too high and even more in those patients with poor compliance regarding their attendance to the thalassemia center.