Introduction: COVID-19 is primarily a respiratory illness caused by the novel coronavirus SARS-CoV-2. However, it can also affect other organ systems, including the hematological system. This study aimed to compare haematological parameters and inflammatory markers between COVID-19 positive patients and a control group without COVID-19, providing valuable insights into potential coagulation and inflammatory responses in COVID-19.

Material and Methods: A total of 100 COVID-19 positive patients and 100 individuals without COVID-19 (control group) were included in the study at Mamata Academy of Medical Sciences, Hyderabad. Haematological parameters, including haemoglobin, leukocyte, neutrophil, lymphocyte, monocyte, and platelet counts, along with prothrombin time and C-reactive protein (CRP) levels, were measured in both groups. Additionally, the levels of D-dimer and Interleukin-6 (IL-6) were quantified as essential markers for coagulation and inflammation, respectively.

Results: The mean D-dimer value in COVID-19 positive patients was 143.45 mg/L (± 15.98), while the mean IL-6 value was 45.6 pg/mL (± 6.2). There were no statistically significant differences (p>0.05) observed in any of the measured haematological parameters or inflammatory markers between the COVID-19 positive and control groups, indicating that their haematological profiles were comparable.