The use of 100 units of blood in 100 patients received over a period of 3 months from the beginning of February to terminal of April. Reaction reported after transfusion of 100 units of whole blood only. 38 case of transfusion reaction occurring at maternity and pediatric hospital in Al-Najaf. Fever and chills was commonest manifestation and the most frequent presenting symptoms 70 patients develop reaction with few minutes of starting of transfusion with few drops of blood. 3 patient develop reaction after finishing transfusion with few minutes 5 patient develop reaction during transfusion. All pregnant women had more reaction occur in blood group O +ve more reaction occur with frequent blood transfusion. Indication for blood transfusion more in anemia.36% inappropriately transfused. 1.2% incidence of blood transfusion reaction in hospital.