The study was conducted on 75 patients who fulfilled the diagnostic criteria of knee osteoarthritis (OA) established by the ACR and radiological finding, another group consists of 50 subjects who had no history of knee pain or clinical signs of asymptomatic OA. The aim of this study was to see whether OA of the knees is only a knee aging process or is part of systemic aging. Furthermore the impact of knees OA on general health score Short Form- 12 (SF-12) & its association with aging disorders especially cardiovascular diseases (CVD). The parameters studied including; body mass index (BMI), hand grip strength, electrocardiography (ECG), erythrocyte sedimentation rate (ESR), C- reactive protein (CRP) and malondialdehyde (MDA)and data about co-morbidities including; hypertension (HT), Hyperlipidemia, coronary heart disease (CHD), heart failure (HF), cerebrovascular accident (CVA) and diabetes mellitus (DM) were obtained by questioning subjects or from clinica and laboratory evaluation of cardiac chest pain, HF, Blood pressure, random blood sugar (RBS) and non-fasting serum cholesterol of all patients and control individuals. In addition health related quality of life (HRQoL) and general health was assessed by means of Short form- 12 (SF-12) questionnaire and the data were licensed and scored by the Quality Metric Incorporated/ Health outcomes Scoring Software. The results obtained from the study revealed that knee OA is age related diseases and it is more common in women (90.6% than men. Obesity was present in 80% of patients while was present in 32% of control (P<0.01) and this results confirmed the strong association between obesity and OA knee but not with overweight. Patients were significantly more likely to have high levels of comorbidity than controls (85.3% of osteoarthritic patients have co-morbid conditions, while it was in 46% in control (P<0.01) and the study had been demonstrated that CVD (HT, HF, CHD, Hyprlipidemia) being most common co-morbidities (82.6% patients had CVD while it is found in 42% of the control, so highly significant difference is fond between patients and control, P<0.01). The results of this study revealed that OA and co-morbidities associated with elevated inflammatory markers (ESR and CRP) compared to control (P<0.01, P<0.05 respectively). Furthermore OA and co-morbidities associated with elevation of oxidative stress (MDA) so a highly significant difference in comparison to control had been found (P<0.01). The grip strength of dominant hand found to be much lower than control with highly significant difference (P<0.01). OA and co-morbidities such as, HT, CHD and DM considered to have great influence on patients' outcome in this study. The results of general health score (SF-12) showed that health status of patients was worse than control with a significant statistical difference (P<0.5, P<0.01respectivel). This revealed that comorbidity in patients with OA of the knee is negatively affect the general health status and HRQoL of individuals.