Advancement in the medical field has led to the introduction of different types and techniques of anesthesia for limiting the complications posed by anesthesia for patients undergoing major surgical procedures. Nevertheless, general factors such as nausea, vomiting, headache, cardiac complications, and respiratory diseases are hard to avoid after a prolonged surgical process. A cross-sectional study design conducted on 87 participants of varying ages, gender, and physical status was conducted in this study. Statistical testing using the chi-square technique indicated that the factors were not independent of the complications of anesthesia. The findings indicated that general and respiratory complications were more common than cardiac problems. These factors, on the other hand, are also dependent on the type of anesthesia, duration, and co-existing patient conditions. Moreover, results confirmed the proportion of complications in the male patients more than the female (52.2%, 47.8%), especially at the age (24-35 years; 29.9%), among smokers (20.9%), patients with hypertension (20.9%), obesity (13.4%), drug allergy (14.9%), having general type of anesthesia (67.2%), with a duration above 30 minutes (65.7%). However, most of the relationships are found statistically insignificant. Complications are in the form of vomiting, nausea, headache, obstruction of the airway, respiratory spasm, Apnea, hypotension, Cardiac arrhythmia, type of anesthesia. Overall, the study concluded that risk factors are directly proportional to the underlying complications.