Objective: The purpose of the study was to identify the size parameters of the small glands of the vaginal vestibule with some developmental anomalies of the internal genital organs. Material and methods. Microscopic method was used to study the glands of the vaginal vestibule in 18 newborn girls with anomalies of the internal genital organs. Fixed pieces after alcohol treatment were poured into paraffin. Sections 5-7 microns thick were stained with hematoxylin-eosin and van Gieson. A reaction was conducted on Craigberg. Results: The analysis showed that, in norm, the small glands of the vestibule of the child's vagina at the time of birth are capable of active secretion. In newborn girls with anomalies of the urogenital apparatus, the thickness and area of ​​the initial section, the number of initial parts, the area of ​​the initial part on the cut, the number of glandulocytes in the initial part of the glands decreases.