Background:Chronic kidney disease (CKD) is identified as a global health problem touching about 17.2% of the Indian population and 11 to 13% globally. Gastrointestinal symptoms are common findings in patients with CKD. Aims and Objectives:To evaluate the various symptoms and prevalence of upper gastrointestinal endoscopic lesion of gastrointestinal system among patient with CKD. Materials and Methods: Hundred patients with CKD were studied in the Department of Medicine, Gandhi Medical College and associated Hamidia Hospital from February 2017 to January 2018. Patients were divided into different stages as Stage I to Stage V based on the GFR values. We collected age, sex, weight, detailed history of patient with special reference to gastrointestinal symptoms like nausea, vomiting, anorexia, hiccups, abdominal pain, hemetemesis. All the patients had undergone upper gastrointestinal endoscopy (UGIE). Results:Mean age of patients in study cohort was 44.30±10.67 years with male (56%) preponderance. Majority were on were on hemodialysis (53%). Out of 100 CKD patients studied, the 48 patients were in the CKD stage 5 and all were under hemodialysis. 82% patients had the lesion on UGI Endoscopy. Patients who were on HD they had more lesion on UGI Endoscopy (p =0.003). CKD severity and stages progresses the lesion on UGI Endoscopy increases (p=0.02). UGI Endoscopic lesion is more common in CKD with duration of disease is > 2years (P= 0.023). Most common GI symptoms were nausea (90%) and heart burn (90%) followed abdominal pain (85%) and abdominal distension (85%). Most common UGIE lesions was pangastritis (25%) followed by duodenitis (22%) and esophagitis (16%). UGI Endoscopic lesions were more common CKD stage 5 followed by CKD stage 4. Endoscopy was more common to be found when duration of disease is more than 2 years. Conclusion: Gastrointestinal symptoms are common in CKD patients and constitute an important cause of seeking medical care among these patients. Upper GI symptoms like nausea, vomiting and abdominal pain tend to worsen with increasing uremia. Patients with higher grading of CKD showed higher incidence of abnormalities of GI findings on endoscopy.