Superficial infections of the skin and nails are the most common fungal diseases in humans and affect ~25% (or ~1.7 billion) of the general population worldwide. Griseofulvin is antifungal antibiotic drug which is practically insoluble in water. (BCS class II) like other candidates in this class, it has solubility limited bioavailability. Solid dispersion is one of the widely and effective used techniques for solubility enhancement. The solid dispersions were prepared by physical mixing, kneading method, melting or fusion and solvent evaporation method using PEG 6000, PEG 4000, poloxamer 188, poloxamer 407 and crospovidone as polymer with ratio 1:1, 1:3, 1:5, 1:7 then formulating solid dispersion tablets of the best formulation of solid dispersion. Tablets formulations were prepared by direct compression technique using super disintegrants crospovidone, croscarmellose sodium and sodium starch glycolate in different concentrations. solid dispersion were evaluated for FTIR, DSC, in vitro dissolution profiles and developed tablets formulations were evaluated for various pharmaceutical characteristics viz. hardness, percentage friability, weight variation, drug content, disintegration time, wetting time, in vitro dissolution profiles. Among different formulations of solid dispersion, solid dispersion containing drug to polymer ratio 1: 1 (griseofulvin: crospovidone) gives best dissolution profile. The study reveals that the formulation F4 (6% of crospovidone) is found to be the optimized formulation with 98.23% drug release in 10 minutes and disintegration is found to be in (25sec.) in comparison with other super disintegrants. Results showed that crospovidone is a promising polymer for enhancing the solubility of griseofulvin.