Objectives: To assess the health related quality of life in stroke patients using Stroke Impact Scale Version 3.0 in a tertiary care hospital. Methods: A Prospective observational study was conducted in75 stroke patients for a period of 6 months in Vivekanandha Medical Care Hospital, Elayampalayam. Baseline characteristics in stroke patients were analysed and counseling was provided using patient information leaflet. Health related quality of life was assessed at baseline and after 90 days follow up using SIS version 3.0 questionnaire. Results: Health related quality of life was mainly affected in social participation (13.2 ± 10.7) and mobility (15.8 ± 11.1) domains at baseline. The mean differences were higher among the domains of strength (37.4 ± 2.0), mobility (34.4 ± 0.6) and memory (29.1 ± 2.1).The least mean differences were observed in the domains of emotion (16.7 ± 0.9). Significant improvement was found in all the domains (P value<0.05) during follow up. Conclusion: Stroke can leave an individual with residual impairment of physical, psychological, social and cognitive function which affects their health related quality of life. Educating the patients using leaflet and pharmaceutical care after stroke can improve health related quality of life.