Initially, the host responds to plasmodial infection by activating nonspecific defence mechanisms. Splenic immunologic and filtrative clearance functions are augmented in malaria. Nonspecific host defence mechanisms stop the infection’s expansion, and the subsequent specific immune response controls the infection. Eventually, exposure to sufficient strains confers protection from high-level parasitemia and disease but not from infection. As a result of this state of infection without illness (premunition), asymptomatic parasitemia is common among adults and older children living in regions with stable and intense transmission. This study was conducted among adult patients of falciparum malaria. All Adults patients (>14 yrs.) with positive asexual forms of malaria in thick smear, thin smear or positive QBC/ICT test admitted to the hospital were included in the study. Fever was the most common symptom, present in 96.6% of the patients. Other symptoms were vomiting (60%), headache (66.6%), weakness (fatigue) 38.3%, Hepatomegaly and spleenomegaly was present 16.6% and 26.6% respectively.