Introduction: Profunda femoris artery arises on the posterolateral aspect of femoral artery about 3.5 cm distal to inguinal ligament in femoral triangle. Profunda femoris artery (PFA) is the largest branch of femoral artery which supplies all the muscles of thigh. During the procedures like arterial catheterization damage to PFA may invite unwanted and unexpected complications. To minimise complications precise anatomy of PFA is important.

Method and Material: Femoral triangles of 70 lower limbs of 29 male and 6 female embalmed cadavers were dissected to study origin, course and branches of PFA. The external diameter of femoral artery and PFA was measured.

Results: In all the lower limbs PFA was present and in majority of cases the commonest site of origin was posterolateral aspect of femoral artery. The mean distance from inguinal ligament from where PFA was arising from femoral artery was 3.2 cm. In majority of lower limbs lateral circumflex femoral artery was arising from PFA.

Conclusion: Point of origin of PFA was similar in some cases and different in other cases. Detail knowledge regarding variations in point of origin, branches of PFA is clinically significant and should not be ignored.