Introduction: In India, there were approximately 29.8 million patients with cardiovascular disease by the year 2003, 1.5 million people die every year. Compared with all other countries, India suffers the highest loss in potentially productive years of life, due to deaths from cardiovascular disease in people with age 35-64 years. Objectives: The present study was undertaken to know the risk factors and co morbidities associated acute myocardial infarction (AMI). Methodology: This cross sectional study was carried out in Basaveshwar teaching & General Hospital, attached to M.R. Medical college, Kalaburagi. The study sample included all the patients admitted to medicine ward of Basaveshwar Teaching and General Hospital, Kalaburagi with the history of chest pain suggestive of AMI as diagnosed by WHO criteria during the study period. The period of study was from June 2012 to June 2014. SPSS 20 was used for statistical analysis to find the association of risk factors and co morbidities of AMI. Result: Acute myocardial infarction (AMI) was more common in men than women and the incidence of which was higher in the age group of 5l-60 years in both sexes. The highest risk factor for AMI was smoking followed by hypertension and obesity. Maximum number of AMI cases (80%) were admitted in the ICCU ward within 12 hours of onset of chest pain. Conclusion: AMI is more commonly seen during the age group of 41-70 years. Males are affected at an earlier age as compared to females. Smoking if the major risk factor significantly associated with AMI. Hypertension is the co morbid condition significantly associated with AMI.