Background: Rational drug utilization must be promoted in patients with type 2 diabetes mellitus (T2DM) as it is emerging as one of the major health related issue leading to increase in rate of morbidity and mortality. Aims and Objective: To study drug utilization to assess the prescribing pattern of antidiabetic drugs in patients with diabetes and hypertension. Materials and Methods: In present prospective study, a total 75 patients were studied in Department of Medicine and Department of Pharmacology, L N Medical College and research center Bhopal, Madhya Pradesh from January 2016 to May 2016. After recording patient’s detailed history and physical parameters, prescribing pattern of all the patients diagnosed either as T2DM or hypertensive was assessed. Results: The most commonly prescribed drug was metformin (95%) followed by glimepiride (80%) and gliptins (70%). In present study insulin was the least used drug. Triple drug therapy (40%) was most common followed by dual therapy (29.33%). Use of SGLT2i was significantly high in patients with hypertension as compared to patients with diabetes only (p=0.0006). Telmisartan (67.27%) was the most commonly used antihypertensive drug. Conclusion: Still, among physician OHAs are the drug of choice for the treatment of T2DM as metformin was the most commonly prescribed drug followed by glimepiride.