Background: Early-stage diabetic kidney disease (ESDKD) can predict future renal failure. ESDKD is usually accompanied by glomerular hyper filtration and albuminuria. Several cross sectional studies across the world reported cigarette smoking and its association with elevated GFR in apparently healthy individuals.

Aims and Objective: To evaluate the relationship between cigarette smoking and alteration in GFR and urinary albumin excretion in apparently healthy male subjects.

Material and Methods: Two hundred and thirty subjects were studied after dividing them in to Group S (n=115; smokers) and Group NS (n=115; non smokers) in the Department of Medicine, Gandhi Medical College and Hamidia Hospital, Bhopal from January 2015 to February 2016. A detailed history including age, clinical evaluation including systolic and diastolic blood pressure and laboratory investigation including hemoglobin, serum creatinine and GFR were performed in all the subjects.

Results: The present study included 100 smokers and 100 non smokers. The mean age of the studied patients was 39.85 ±8.15 among smokers and 39.80±7.28 among non-smokers. Among smokers 49% smokers have proteinuria. Proteinuria was significantly associated with pack years among current smokers (p=0.011). Smokers with >40 pack years were found to be significantly associated with proteinuria. Among smokers 67% have high gfr. As compared to non-smokers, current smokers have high GFR (mean=120.06±18.53) High GFR was significantly correlated in smokers with pack year>40 (p=0.025). The average GFR in current smokers is 120.06±18.53.

Conclusion: Current smokers have altered glomerular filtration rate and proteinuria as compared to non smokers. Glomerular filtration rate, proteinuria, high SBP and high DBP significantly correlated with pack years.