The current work has studied the individual, age and gender alteration characteristics of the distance between the middle poserior wall of pterygomaxillary fissure and round foramen in different stages of human postnatal ontogenesis by using cranioscopic, craniometric and variation-statistical methods. According to the results of the research, the mean number of the distance between posterior wall of pterygomaxillary fissure and round foramenis bigger in the left part during the first adulthood period. The comparison conducted between the parts of the adjacent age groups has shown that this distance in menhas a left-sided advantage in the I adulthood and senilityperiod rather than the youth andelderly period, whereas in women the distance has a right-sided advantage in senility period rather than the elderly period. Comparative analysis of sexual variability of this distance indicates its advantage during the I and II adulthood period in men in both sides, during the senile period in the left side and during the elderly period in the right side in comparison to women.