Background: Although Laparoscopic surgery is a minimally invasive surgery, pain after the surgery is acute in character & patient feels discomfort during first 24 – 72 postoperative hours which can delay their discharge. So adequate analgesia is of the utmost importance for early ambulatory & speedy recovery. The use of opioids for pain is associated with side effects such as nausea, vomiting, sedation & respiratory depression. We planned our study to find out the best alternative to opioids for post-operative analgesia in patients undergoing Laparoscopic surgeries.

Method: The study was conducted in 60 patients aged between 18 – 65 years belonging to ASA ׀ & װ undergoing laparoscopic surgery were randomly divided into two groups. Group A received- Inj. Paracetamol @ 15 mg/kg (maximum 1g in 100 ml infusion) over 15-20 minutes 30 minutes before extubation. Group B received- Inj. Diclofenac sodium @ 2 mg/kg (maximum 75 mg) in 100 ml of Normal saline 30 minutes before extubation. Both groups were assessed & general anesthesia was given. A questionnaire was responded by patients & a chart was maintained for pain score in VAS & for side effects. Hemodynamic parameters were recorded.

Results: Hemodynamic changes were similar in both groups in respect of Heart rate & Blood pressure. However Paracetamol infusion provided better hemodynamic stability – both - during & after surgery. Most of the patients in Paracetamol group had VAS score <7 for more than 10 hours after surgery compared to diclofenac group. Patients who were administered Paracetamol infusion had better quality of analgesia & lesser side effects.