Background: In Asian countries about 70% patients suffering from schizophrenia are cared by their family members as compared to 25%-50% in western countries; this put an extra pressure of their routine and cost; early recognition can minimize this burden. Aims and Objective: To study and correlate gluten sensitivity determined by the levels of anti-gliadin antibody (IgG) with duration and psychopathology in schizophrenia. Materials and Methods: A cross-sectional study was performed on 30 schizophrenic patients fulfilling ICD-10 criteria in psychiatry ward of people’s hospital, Bhopal from 2015-2017. Age, gender, total score on Brief Psychiatric Rating Scale version 4.0 (BPRS) and antigliadin antibody (AGA-IgG) titre (U/ml) were studied in all enrolled patients. Each psychotic symptom is rated 1-7 and a total of 24 symptoms are scored. All the data were analyzed using Statistical Package of Social Science Version 20; Chicago Inc., USA. Student t test, paired t test and chi square test were used to establish the level of significance. Significance was assessed at 5% level. Results: Male preponderance was observed among Cases (63.3%) and controls (60%) (P=0.241). Patients having low AGA-IgG (<20) level were significantly high in Controls (n=21) compared to Cases (n=4) (p<0.001) whereas there were significantly more number of patients in Cases (n=17) who had high (>30) AGA-IgG levels compared to Controls (n=1) (p=0.002). BPRS score (r=0.231,p=0.089) and duration of illness (r=0.213, p=0.078) have shown positively correlation with the AGA-IgG values. No significant difference was obtained while comparing AGA-IgG values between gender (p=0.705). Conclusion: Immune pathological abnormalities associated with raised antibodies are present in the course of the disease and may worsen with the disease progression. Hence screening of patients with schizophrenia by laboratory test for Gluten sensitivity can be performed routinely.