Hyperlipidemia also known as hyperlipoproteinemia is a disorder of abnormally high levels of any or all lipids and/or lipoproteins in the blood. Hyperlipidemia itself usually causes no symptoms but can lead to symptomatic vascular disease, including coronary artery disease (CAD) and peripheral arterial disease. Atherosclerosis being the main complication associated with hyperlipidemia is the leading cause of death in the developed and developing countries like India. Treatment of hyperlipidemia is one of the major approaches towards decelerating the atherogenic process. Guggulipid (GL), an extract of Commiphora mukul, has been safely used for thousands of years in the Indian Ayurveda medicine practice for the treatment of different ailments like arthritis, obesity, and other disorders. It has been clinically proven to reduce the levels of harmful serum lipids in the bloodstream. Guggulsterone E and guggulsterone Z which are present in a concentration of 4.0 and 6.0% have been identified as the active ingredients responsible for the maintenance of healthy cholesterol levels. Guggul was introduced as a medicine in 1966, and but approved as a hypolipidemic drug for marketing in India in 1986. In the present paper, an attempt has been made to review the use of guggulipid preparations for hyperlipidemia.