Aim: The present study was conducted to study the presence of bacteremia, markers of sepsis and Inflammation in renal failure patients on hemodialysis, along with correlation of hematological abnormalities with sepsis in such patients.

Material & Methods: The present study was conducted on total of 200 patients of both sexes who were diagnosed as case of renal failure which include both acute kidney injury (AKI) and CKD on basis of clinical history, examination, biochemical markers and were advised for hemodialysis were included in the study.

Results: In our study among 200 patients of renal failure on hemodialysis the mean age in our study was 45.65±15.65 years with 140 male patients. Out of 200 patients 42 (21%) had positive blood and catheter tip culture and 158 (79%) of patients had negative blood and catheter tip culture. Out of 42 patients with sepsis 11 (26.19%) were in the age group between 15–25 years, 26–35 years, 7 (16.66) were in the age group 36–45 years and 13 (30.95) were above 45 years of age. All 42 (100%) patients had episode of fever with chills and rigor, 20 (47.61) patients had redness and pain at hemodialysis catheter site, 14 (33.34) were confused, disoriented or comatose and 10 (23.80) patients had hypotension. Among 42 patients of renal failure with sepsis, none had TLC less than 4.8/cumm (leucopenia), 13 (30.95) patients had count between 4.8–10.8/cumm and 29 (69.05) patients had TLC more than 10.8/cumm. 34 (80.95%) patients’ blood culture was positive for S. aureus, and E. coli found in blood culture 4 (9.52%) patient, Acinectobacter in 2 (4.76%) patient and Candida in 2 (4.76%) patients.