A 34 year old young patient was admitted in medical emergency with history of fever and generalized weakness last 3 days. After 10 minutes of physical examination patient had fainting episode with cardiogenic shock and he was shifted to cardiac ICU. ECG showed low voltage with flat T waves and 2D Echocardiography revealed pericardial abscess without structural heart diseases or coronary heart diseases and no evidence was found for vegetations. Chest X-ray showed cardiomegaly without chamber enlargement. He was treated aggressively for pericardial abscess. Massively raised WBC counts was treated with support of two to three broad spectrum antibiotics and antifungal. Despite of all medical therapy patient did not improved then as per studies and previous papers we started inj Ulinastatin with same antibiotic support. Finally he came out of horrible condition after 3 days.